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  "Title": "Predict Transmembrane Protein Topology",
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  "Description": "Proteins reside in either the cell plasma or in the cell\nmembrane. A membrane protein goes through the membrane at least\nonce. Given the amino acid sequence of a membrane protein, the\ntool 'PureseqTM'\n(<https://github.com/PureseqTM/pureseqTM_package>, as described\nin \"Efficient And Accurate Prediction Of Transmembrane Topology\nFrom Amino acid sequence only.\", Wang, Qing, et al (2019),\n<doi:10.1101/627307>), can predict the topology of a membrane\nprotein. This package allows one to use 'PureseqTM' from R.",
  "License": "GPL-3",
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  "URL": "https://github.com/richelbilderbeek/pureseqtmr/",
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  "Repository": "https://richelbilderbeek.r-universe.dev",
  "Date/Publication": "2026-07-04 09:02:07 UTC",
  "RemoteUrl": "https://github.com/richelbilderbeek/pureseqtmr",
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  "Author": "Richèl J.C. Bilderbeek [aut, cre] (ORCID:\n<https://orcid.org/0000-0003-1107-7049>)",
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  "_created": "2026-10-10T17:17:42.000Z",
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      "version": "1.4.2",
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  "_exports": [
    "are_tmhs",
    "are_valid_protein_sequences",
    "calc_distance_to_tmh_center_from_topology",
    "calc_distance_to_tmh_center_from_topology_str",
    "check_protein_sequence",
    "check_protein_sequences",
    "check_pureseqtm_installation",
    "check_topology",
    "check_topology_str",
    "convert_tmhmm_to_pureseqtm_topology",
    "count_n_tmhs",
    "create_pureseqtm_files",
    "create_pureseqtm_proteome_file",
    "get_default_pureseqtm_folder",
    "get_example_filename",
    "get_example_filenames",
    "get_pureseqtm_url",
    "get_pureseqtm_version",
    "install_pureseqtm",
    "is_on_appveyor",
    "is_on_ci",
    "is_on_github_actions",
    "is_on_travis",
    "is_protein_name_line",
    "is_pureseqtm_installed",
    "is_tmh",
    "is_topology_line",
    "is_valid_protein_sequence",
    "load_fasta_file_as_tibble",
    "load_fasta_file_as_tibble_cpp",
    "load_fasta_file_as_tibble_r",
    "load_topology_file_as_tibble",
    "mock_predict_topologies_from_sequences",
    "mock_predict_topology",
    "parse_pureseqtm_proteome_text",
    "plot_topology",
    "predict_topologies_from_sequences",
    "predict_topology",
    "predict_topology_from_sequence",
    "pureseqtmr_report",
    "run_pureseqtm_proteome",
    "save_tibble_as_fasta_file",
    "tally_tmhs",
    "uninstall_pureseqtm"
  ],
  "_help": [
    {
      "page": "are_tmhs",
      "title": "Are the sequences transmembrance helices?",
      "topics": [
        "are_tmhs"
      ]
    },
    {
      "page": "are_valid_protein_sequences",
      "title": "Determine if these are all valid protein sequences",
      "topics": [
        "are_valid_protein_sequences"
      ]
    },
    {
      "page": "calc_distance_to_tmh_center_from_topology",
      "title": "Calculate the the distance for each amino acid to the center of the TMH",
      "topics": [
        "calc_distance_to_tmh_center_from_topology"
      ]
    },
    {
      "page": "calc_distance_to_tmh_center_from_topology_str",
      "title": "Calculate the the distance for each amino acid to the center of the TMH",
      "topics": [
        "calc_distance_to_tmh_center_from_topology_str"
      ]
    },
    {
      "page": "calc_distance_to_tmh_center_from_topology_str_cpp_stl",
      "title": "Use Rcpp to calculate the distance to a TMH center",
      "topics": [
        "calc_distance_to_tmh_center_from_topology_str_cpp_stl"
      ]
    },
    {
      "page": "check_protein_sequence",
      "title": "Check one protein sequence",
      "topics": [
        "check_protein_sequence"
      ]
    },
    {
      "page": "check_protein_sequences",
      "title": "Check one or more protein sequences",
      "topics": [
        "check_protein_sequences"
      ]
    },
    {
      "page": "check_pureseqtm_installation",
      "title": "Checks the installation of PureseqTM. Throws a helpful error message if incomplete, else does nothing",
      "topics": [
        "check_pureseqtm_installation"
      ]
    },
    {
      "page": "check_topology",
      "title": "Check if the topology is valid.",
      "topics": [
        "check_topology"
      ]
    },
    {
      "page": "check_topology_str",
      "title": "Check if the topology string is valid. Will stop if not.",
      "topics": [
        "check_topology_str"
      ]
    },
    {
      "page": "convert_tmhmm_to_pureseqtm_topology",
      "title": "Convert a TMHMM topology to a PureseqTM topology",
      "topics": [
        "convert_tmhmm_to_pureseqtm_topology"
      ]
    },
    {
      "page": "count_n_tmhs",
      "title": "Count the number of TMHs in a topology",
      "topics": [
        "count_n_tmhs"
      ]
    },
    {
      "page": "create_pureseqtm_files",
      "title": "Create the five PureseqTM output files, by running PureseqTM.",
      "topics": [
        "create_pureseqtm_files"
      ]
    },
    {
      "page": "create_pureseqtm_proteome_file",
      "title": "Create the output file of a PureseqTM proteome run",
      "topics": [
        "create_pureseqtm_proteome_file"
      ]
    },
    {
      "page": "default_params_doc",
      "title": "This function does nothing. It is intended to inherit is parameters' documentation.",
      "topics": [
        "default_params_doc"
      ]
    },
    {
      "page": "get_default_pureseqtm_folder",
      "title": "Get the path to the folder where this package installs PureseqTM by default",
      "topics": [
        "get_default_pureseqtm_folder"
      ]
    },
    {
      "page": "get_example_filename",
      "title": "Get the full path to a PureseqTM example file.",
      "topics": [
        "get_example_filename"
      ]
    },
    {
      "page": "get_example_filenames",
      "title": "Get the full path to all PureseqTM example files",
      "topics": [
        "get_example_filenames"
      ]
    },
    {
      "page": "get_pureseqtm_url",
      "title": "Get the URL of the PureseqTM source code",
      "topics": [
        "get_pureseqtm_url"
      ]
    },
    {
      "page": "get_pureseqtm_version",
      "title": "Get the PureseqTM version",
      "topics": [
        "get_pureseqtm_version"
      ]
    },
    {
      "page": "install_pureseqtm",
      "title": "Install PureseqTM to a local folder",
      "topics": [
        "install_pureseqtm"
      ]
    },
    {
      "page": "is_on_appveyor",
      "title": "Determines if the environment is AppVeyor",
      "topics": [
        "is_on_appveyor"
      ]
    },
    {
      "page": "is_on_ci",
      "title": "Determines if the environment is a continuous integration service",
      "topics": [
        "is_on_ci"
      ]
    },
    {
      "page": "is_on_github_actions",
      "title": "Determines if the environment is GitHub Actions",
      "topics": [
        "is_on_github_actions"
      ]
    },
    {
      "page": "is_on_travis",
      "title": "Determines if the environment is Travis CI",
      "topics": [
        "is_on_travis"
      ]
    },
    {
      "page": "is_protein_name_line",
      "title": "Is the line of text the name of a protein, as used within a FASTA filename?",
      "topics": [
        "is_protein_name_line"
      ]
    },
    {
      "page": "is_pureseqtm_installed",
      "title": "Measure if PureseqTM is installed locally",
      "topics": [
        "is_pureseqtm_installed"
      ]
    },
    {
      "page": "is_tmh",
      "title": "Determine if the protein sequence contains at least one transmembrane helix.",
      "topics": [
        "is_tmh"
      ]
    },
    {
      "page": "is_topology_line",
      "title": "Is the line of text the topology, as used within a FASTA filename?",
      "topics": [
        "is_topology_line"
      ]
    },
    {
      "page": "is_valid_protein_sequence",
      "title": "Determine if this a valid protein sequence",
      "topics": [
        "is_valid_protein_sequence"
      ]
    },
    {
      "page": "load_fasta_file_as_tibble",
      "title": "Parse a FASTA file to a table with a 'name' and 'sequence' column",
      "topics": [
        "load_fasta_file_as_tibble"
      ]
    },
    {
      "page": "load_fasta_file_as_tibble_cpp",
      "title": "Parse a FASTA file to a table with a 'name' and 'sequence' column",
      "topics": [
        "load_fasta_file_as_tibble_cpp"
      ]
    },
    {
      "page": "load_fasta_file_as_tibble_cpp_raw",
      "title": "Use Rcpp to load a FASTA file",
      "topics": [
        "load_fasta_file_as_tibble_cpp_raw"
      ]
    },
    {
      "page": "load_fasta_file_as_tibble_r",
      "title": "Parse a FASTA file to a table with a 'name' and 'sequence' column",
      "topics": [
        "load_fasta_file_as_tibble_r"
      ]
    },
    {
      "page": "load_topology_file_as_tibble",
      "title": "Parse a topology ('.topo') file to a table with a 'name' and 'topology' column",
      "topics": [
        "load_topology_file_as_tibble"
      ]
    },
    {
      "page": "mock_predict_topologies_from_sequences",
      "title": "Do a mock prediction directy on a protein sequence, as can be useful in testing Use predict_topologies_from_sequences for doing a real prediction.",
      "topics": [
        "mock_predict_topologies_from_sequences"
      ]
    },
    {
      "page": "mock_predict_topology",
      "title": "Do a mock prediction of the topology of proteins",
      "topics": [
        "mock_predict_topology"
      ]
    },
    {
      "page": "parse_pureseqtm_proteome_text",
      "title": "Parse the output of a call to 'PureseqTM_proteome.sh'",
      "topics": [
        "parse_pureseqtm_proteome_text"
      ]
    },
    {
      "page": "plot_topology",
      "title": "Plot the topology",
      "topics": [
        "plot_topology"
      ]
    },
    {
      "page": "predict_topologies_from_sequences",
      "title": "Run PureseqTM directy on a protein sequence",
      "topics": [
        "predict_topologies_from_sequences"
      ]
    },
    {
      "page": "predict_topology",
      "title": "Predict the topology of proteins from file",
      "topics": [
        "predict_topology"
      ]
    },
    {
      "page": "predict_topology_from_sequence",
      "title": "Run PureseqTM directy on a protein sequence",
      "topics": [
        "predict_topology_from_sequence"
      ]
    },
    {
      "page": "pureseqtmr_report",
      "title": "Create a pureseqtmr report, to be used when reporting bugs",
      "topics": [
        "pureseqtmr_report"
      ]
    },
    {
      "page": "run_pureseqtm_proteome",
      "title": "Run PureseqTM on a proteome",
      "topics": [
        "run_pureseqtm_proteome"
      ]
    },
    {
      "page": "save_tibble_as_fasta_file",
      "title": "Save the first two columns of a tibble as a FASTA file",
      "topics": [
        "save_tibble_as_fasta_file"
      ]
    },
    {
      "page": "tally_tmhs",
      "title": "Count the number of transmembrane helices in a topology",
      "topics": [
        "tally_tmhs"
      ]
    },
    {
      "page": "uninstall_pureseqtm",
      "title": "Uninstall PureseqTM",
      "topics": [
        "uninstall_pureseqtm"
      ]
    }
  ],
  "_readme": "https://github.com/richelbilderbeek/pureseqtmr/raw/HEAD/README.md",
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